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Drug-Loaded Mesoporous Silica Nanoparticles Enhance Antitumor Immunotherapy by Regulating MDSCs.
Xu, Changlin; Amna, Nida; Shi, Yuchen; Sun, Rong; Weng, Chenhui; Chen, Jiaoyu; Dai, Huaxing; Wang, Chao.
Afiliación
  • Xu C; Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Function Materials and Devices, Soochow University, Suzhou 215123, China.
  • Amna N; Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Function Materials and Devices, Soochow University, Suzhou 215123, China.
  • Shi Y; Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Function Materials and Devices, Soochow University, Suzhou 215123, China.
  • Sun R; Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Function Materials and Devices, Soochow University, Suzhou 215123, China.
  • Weng C; Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Function Materials and Devices, Soochow University, Suzhou 215123, China.
  • Chen J; Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Function Materials and Devices, Soochow University, Suzhou 215123, China.
  • Dai H; Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Function Materials and Devices, Soochow University, Suzhou 215123, China.
  • Wang C; Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Function Materials and Devices, Soochow University, Suzhou 215123, China.
Molecules ; 29(11)2024 May 22.
Article en En | MEDLINE | ID: mdl-38893313
ABSTRACT
Myeloid-derived suppressor cells (MDSCs) are recognized as major immune suppressor cells in the tumor microenvironment that may inhibit immune checkpoint blockade (ICB) therapy. Here, we developed a Stattic-loaded mesoporous silica nanoparticle (PEG-MSN-Stattic) delivery system to tumor sites to reduce the number of MDSCs in tumors. This approach is able to significantly deplete intratumoral MSDCs and thereby increase the infiltration of T lymphocytes in tumors to enhance ICB therapy. Our approach may provide a drug delivery strategy for regulating the tumor microenvironment and enhancing cancer immunotherapy efficacy.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Dióxido de Silicio / Nanopartículas / Microambiente Tumoral / Células Supresoras de Origen Mieloide / Inmunoterapia Límite: Animals / Humans Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China
Texto completo
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Dióxido de Silicio / Nanopartículas / Microambiente Tumoral / Células Supresoras de Origen Mieloide / Inmunoterapia Límite: Animals / Humans Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China