Eribulin induces micronuclei and enhances the nuclear localization of cGAS in triple-negative breast cancer cells.
Sci Rep
; 14(1): 14146, 2024 06 19.
Article
en En
| MEDLINE
| ID: mdl-38898119
ABSTRACT
Eribulin (ERI), clinically utilized for locally advanced or metastatic breast tumors, has shown potential links to the immune system. Notably, the cGAS-STING pathway, a key component of innate immunity, has gained prominence. Yet, limited reports explore ERI's effects on the cGAS-STING pathway. Additionally, the nuclear presence of cGAS remains poorly understood. This study uniquely delves into ERI's impact on both the cytosolic cGAS-STING pathway and nuclear cGAS. ERI enhances nuclear localization of cGAS, resulting in hyper-activation of the cGAS-STING pathway in triple-negative breast cancer cells. Reduction of cGAS heightened both cell proliferation and ERI sensitivity. In clinical data using ERI in a neo-adjuvant setting, patients with low cGAS cases exhibited reduced likelihood of achieving pathological complete response after ERI treatment. These findings illuminate the potential of cGAS and IFNß as predictive biomarkers for ERI sensitivity, providing valuable insights for personalized breast cancer treatment strategies.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Núcleo Celular
/
Neoplasias de la Mama Triple Negativas
/
Furanos
/
Cetonas
/
Nucleotidiltransferasas
Límite:
Female
/
Humans
Idioma:
En
Revista:
Sci Rep
Año:
2024
Tipo del documento:
Article
País de afiliación:
Japón