Talaesthanes A-C, three new meroterpenoids from the endophytic fungus Talaromyces primulinus H21.
Fitoterapia
; 177: 106085, 2024 Sep.
Article
en En
| MEDLINE
| ID: mdl-38901806
ABSTRACT
Three new meroterpenoids (1-3) and ten known ones (4-13) were obtained from the endophytic fungus Talaromyces primulinus H21 isolated from the plant of Euphorbia sikkimensis. Their structures including their absolute configurations were elucidated by extensive analysis of spectroscopic data such as HR-ESI-MS, 1D/2D NMR, and X-ray diffraction of single crystal together with comparison of experimental ECD with calculated ECD. All compounds were examined for their inhibitory effects on nitric oxide (NO) production induced by lipopolysaccharide (LPS) in RAW264.7 cells, and compounds 3, 9, 12, and 13 exhibited certain inhibition on NO production, with IC50 values of 27.19, 41.55, 25.23, and 24.71 µM, respectively.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Terpenos
/
Talaromyces
/
Óxido Nítrico
Límite:
Animals
País/Región como asunto:
Asia
Idioma:
En
Revista:
Fitoterapia
Año:
2024
Tipo del documento:
Article
País de afiliación:
China