Differences in intestinal bacteria in traumatic injury survivors with and without probable posttraumatic stress disorder.
J Affect Disord
; 361: 528-535, 2024 Sep 15.
Article
en En
| MEDLINE
| ID: mdl-38914163
ABSTRACT
BACKGROUND:
Posttraumatic stress disorder (PTSD) is a common consequence of traumatic injury, yet certain biological factors contributing to PTSD are poorly understood. The gut microbiome may influence mental health outcomes, but its role in heterogeneous PTSD presentations requires elucidation.METHODS:
Bacterial composition was examined in adults 2-4 years post-trauma with probable PTSD (n = 24) versus trauma-exposed controls without probable PTSD (n = 24). 16S rRNA sequencing and bioinformatic tools assessed microbial diversity and abundance. Relationships between taxa and PTSD symptom clusters were evaluated.RESULTS:
No differences were found in overall microbial community structure between groups. The probable PTSD group exhibited significantly reduced Actinobacteriota and increased Verrucomicrobiota phylum abundance compared to controls. Specific taxa showed notable inverse associations with negative mood/cognition versus hyperarousal symptoms. Prevotella and Ruminococcaceae were negatively associated with negative mood but positively associated with hyperarousal.CONCLUSIONS:
Results demonstrate microbial signatures of probable PTSD subtypes, highlighting the microbiome as a potential mediator of heterogeneous trauma psychopathology. Definition of PTSD microbial correlates provides a foundation for personalized psychobiotic interventions targeting predominant symptom profiles.Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Trastornos por Estrés Postraumático
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Sobrevivientes
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Microbioma Gastrointestinal
Límite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
J Affect Disord
Año:
2024
Tipo del documento:
Article