Pan-cancer analysis of PSCA that is associated with immune infiltration and affects patient prognosis.
PLoS One
; 19(6): e0298469, 2024.
Article
en En
| MEDLINE
| ID: mdl-38917176
ABSTRACT
Prostate stem cell antigen (PSCA) is associated with disease progression, promotion of angiogenesis, invasion, metastasis and immune evasion in cancer. However, its expression pattern and diagnostic and prognostic potential have not been thoroughly analysed from a pan-cancer perspective. This study aimed to examine the effects of PSCA on the prognosis and inflammatory cell infiltration patterns of various cancer types. We analysed the relationship between PSCA expression and immunological subtypes in tumor microenvironment (TME) and the role of molecular subtypes, potentially promising immune biomarkers and tumour-infiltrating lymphocytes (TILs) in various cancer types, especially lung adenocarcinoma (LUAD). In addition, we investigated the prognostic significance of PSCA expression in LUAD. The co-expression network of PSCA was found to be mainly involved in the regulation of immune responses and antigen processing and expression and was significantly enriched in pathological and substance metabolism-related pathways in cancer. Altogether, this study reveals that PSCA is a promising target for immunotherapy in patients with cancer.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Linfocitos Infiltrantes de Tumor
/
Proteínas Ligadas a GPI
/
Microambiente Tumoral
/
Antígenos de Neoplasias
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Proteínas de Neoplasias
Límite:
Humans
/
Male
Idioma:
En
Revista:
PLoS One
Asunto de la revista:
CIENCIA
/
MEDICINA
Año:
2024
Tipo del documento:
Article
País de afiliación:
China