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New Cyclic Pentapeptides from the Mangrove-Derived Aspergillus fumigatus GXIMD 03099.
Wang, Yu; Cao, Guangping; Gan, Yuman; Lin, Xiao; Yi, Xiangxi; Zhao, Longyan; Liu, Yonghong; Gao, Chenghai; Bai, Meng.
Afiliación
  • Wang Y; Guangxi Key Laboratory of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, China.
  • Cao G; Institute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, China.
  • Gan Y; Guangxi Key Laboratory of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, China.
  • Lin X; Institute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, China.
  • Yi X; Guangxi Key Laboratory of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, China.
  • Zhao L; Institute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, China.
  • Liu Y; Guangxi Key Laboratory of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, China.
  • Gao C; Institute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, China.
  • Bai M; Guangxi Key Laboratory of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, China.
Mar Drugs ; 22(6)2024 Jun 16.
Article en En | MEDLINE | ID: mdl-38921593
ABSTRACT
Four new cyclic pentapeptides, avellanins D-G (1-4), together with four known compounds (5-8), were isolated from a mangrove-derived Aspergillus fumigatus GXIMD 03099 fungus from Acanthus ilicifolius L. Their structures were elucidated by analysis of HRESIMS, NMR, and ESI-MS/MS data. Their absolute configurations were determined by X-ray diffraction analysis and Marfey's method. Compounds 1-8 were screened for insecticidal and antibacterial activities. Compound 2 showed insecticidal activity against newly hatched larvae of Culex quinquefasciatus with an LC50 value of 86.6 µM; compound 4 had weak activity against Vibrio harveyi with an MIC value of 5.85 µM.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Péptidos Cíclicos / Aspergillus fumigatus / Pruebas de Sensibilidad Microbiana / Insecticidas / Antibacterianos Límite: Animals Idioma: En Revista: Mar Drugs Asunto de la revista: BIOLOGIA / FARMACOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Péptidos Cíclicos / Aspergillus fumigatus / Pruebas de Sensibilidad Microbiana / Insecticidas / Antibacterianos Límite: Animals Idioma: En Revista: Mar Drugs Asunto de la revista: BIOLOGIA / FARMACOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China