Anticancer immune reaction and lymph node sinus macrophages: a review from human and animal studies.
J Clin Exp Hematop
; 64(2): 71-78, 2024.
Article
en En
| MEDLINE
| ID: mdl-38925976
ABSTRACT
Lymph nodes are secondary lymphoid organs localized throughout the body that typically appear as bean-like nodules. Numerous antigen-presenting cells, including dendritic cells and macrophages, that mediate host defense responses against pathogens, such as bacteria and viruses, reside within lymph nodes. To react to cancer cell-derived antigens in a variety of cancers, antigen-presenting cells induce cytotoxic T lymphocytes (CTLs). In relation to anticancer immune responses, macrophages in the lymph node sinus have been of particular interest because a number of studies involving both human specimens and animal models have reported that lymph node macrophages expressing CD169 play a key role in activating anticancer CTLs. Recent studies have indicated that dysfunction of lymph node macrophages potentially contributes to immune suppression in elderly patients and immunological "cold" tumors. Therefore, in anticancer therapy, the regulation of lymph node macrophages is a potentially promising approach.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Ganglios Linfáticos
/
Macrófagos
/
Neoplasias
Límite:
Animals
/
Humans
Idioma:
En
Revista:
J Clin Exp Hematop
Asunto de la revista:
HEMATOLOGIA
/
PATOLOGIA
Año:
2024
Tipo del documento:
Article
País de afiliación:
Japón