Molecular mechanisms of diabetic nephropathy: A narrative review.
Cell Biol Int
; 48(9): 1240-1253, 2024 Sep.
Article
en En
| MEDLINE
| ID: mdl-38946126
ABSTRACT
Diabetic nephropathy (DN) is the predominant secondary nephropathy resulting in global end-stage renal disease. It is attracting significant attention in both domestic and international research due to its widespread occurrence, fast advancement, and limited choices for prevention and treatment. The pathophysiology of this condition is intricate and involves multiple molecular and cellular pathways at various levels. This article provides a concise overview of the molecular processes involved in the development of DN. It discusses various factors, such as signaling pathways, cytokines, inflammatory responses, oxidative stress, cellular damage, autophagy, and epigenetics. The aim is to offer clinicians a valuable reference for DN's diagnosis, treatment, and intervention.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Autofagia
/
Transducción de Señal
/
Estrés Oxidativo
/
Nefropatías Diabéticas
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Cell Biol Int
Año:
2024
Tipo del documento:
Article
País de afiliación:
China