Hypervalent iodine-catalyzed amide and alkene coupling enabled by lithium salt activation.
Beilstein J Org Chem
; 20: 1405-1411, 2024.
Article
en En
| MEDLINE
| ID: mdl-38952958
ABSTRACT
Hypervalent iodine catalysis has been widely utilized in olefin functionalization reactions. Intermolecularly, the regioselective addition of two distinct nucleophiles across the olefin is a challenging process in hypervalent iodine catalysis. We introduce here a unique strategy using simple lithium salts for hypervalent iodine catalyst activation. The activated hypervalent iodine catalyst allows the intermolecular coupling of soft nucleophiles such as amides onto electronically activated olefins with high regioselectivity.
Texto completo:
1
Base de datos:
MEDLINE
Idioma:
En
Revista:
Beilstein J Org Chem
Año:
2024
Tipo del documento:
Article
País de afiliación:
Estados Unidos