Adverse drug reactions, adherence, and virologic outcomes in adult patients on dolutegravir-based antiretroviral therapy at a tertiary hospital, southeast Nigeria.
Ghana Med J
; 58(1): 101-108, 2024 Mar.
Article
en En
| MEDLINE
| ID: mdl-38957273
ABSTRACT
Objective:
To assess the adherence, adverse drug reactions (ADR), and virologic outcomes of dolutegravir-based antiretroviral therapy.Design:
This was a retrospective chart review.Setting:
A tertiary health facility-based study in Abakaliki, Nigeria.Participants:
Five hundred and fifteen (515) adult patients on dolutegravir were selected using a Random Number Generator. Demographic and clinical data were extracted from patients' case notes and analysed with IBM-SPSS version-25. Main outcomemeasures:
Adherence to dolutegravir, ADRs, virologic outcome, and change in Body Mass Index (BMI) were estimated.Results:
The mean age of the patients was 45.5±10.8 years; 68.2% of them were females; 97.1% of them had good self-reported adherence. The majority (82.9%) of them reported no ADRs and among those (17.1%) that did, headache (9.7%), body-itching (3.1%), and skin rash (2.7%) dominated. Most achieved viral suppression (94.4%) and did not have detectable viral particles (57.4%). There was a significant increase in the BMI of the patients with a mean weight increase of 0.9kg, a mean BMI increase of 0.3 kg/m2, and a 2.6% increase in the prevalence of overweight and obesity.Conclusions:
Patients on dolutegravir reported low ADRs, good self-reported adherence, and a high viral suppression rate. However, dolutegravir is associated with weight gain. We recommend widespread use and more population-wide studies to elucidate the dolutegravir-associated weight gain.Funding:
None declared.Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Oxazinas
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Piperazinas
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Piridonas
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Índice de Masa Corporal
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Infecciones por VIH
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Inhibidores de Integrasa VIH
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Cumplimiento de la Medicación
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Centros de Atención Terciaria
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Compuestos Heterocíclicos con 3 Anillos
Límite:
Adult
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Female
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Humans
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Male
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Middle aged
País/Región como asunto:
Africa
Idioma:
En
Revista:
Ghana Med J
Año:
2024
Tipo del documento:
Article