Repurposing FDA-approved drugs to treat chemical weapon toxicities: Interactive case studies for trainees.
Pharmacol Res Perspect
; 12(4): e1229, 2024 Aug.
Article
en En
| MEDLINE
| ID: mdl-38965070
ABSTRACT
The risk of a terrorist attack in the United States has created challenges on how to effectively treat toxicities that result from exposure to chemical weapons. To address this concern, the United States has organized a trans-agency initiative across academia, government, and industry to identify drugs to treat tissue injury resulting from exposure to chemical threat agents. We sought to develop and evaluate an interactive educational session that provides hands-on instruction on how to repurpose FDA-approved drugs as therapeutics to treat toxicity from exposure to chemical weapons. As part of the Rutgers Summer Undergraduate Research Fellowship program, 23 undergraduate students participated in a 2-h session that included (1) an overview of chemical weapon toxicities, (2) a primer on pharmacology principles, and (3) an interactive session where groups of students were provided lists of FDA-approved drugs to evaluate potential mechanisms of action and suitability as countermeasures for four chemical weapon case scenarios. The interactive session culminated in a competition for the best grant "sales pitch." From this interactive training, students improved their understanding of (1) the ability of chemical weapons to cause long-term toxicities, (2) impact of route of administration and exposure scenario on drug efficacy, and (3) re-purposing FDA-approved drugs to treat disease from chemical weapon exposure. These findings demonstrated that an interactive training exercise can provide students with new insights into drug development for chemical threat agent toxicities.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
United States Food and Drug Administration
/
Sustancias para la Guerra Química
/
Reposicionamiento de Medicamentos
Límite:
Humans
País/Región como asunto:
America do norte
Idioma:
En
Revista:
Pharmacol Res Perspect
Año:
2024
Tipo del documento:
Article
País de afiliación:
Estados Unidos