A temperature compensated fiber probe for highly sensitive detection in virus gene biosensing.
Anal Chim Acta
; 1316: 342820, 2024 Aug 08.
Article
en En
| MEDLINE
| ID: mdl-38969422
ABSTRACT
This research presents an innovative reflective fiber optic probe structure, mutinously designed to detect H7N9 avian influenza virus gene precisely. This innovative structure skillfully combines multimode fiber (MMF) with a thin-diameter seven-core photonic crystal fiber (SCF-PCF), forming a semi-open Fabry-Pérot (FPI) cavity. This structure has demonstrated exceptional sensitivity in light intensity-refractive index (RI) response through rigorous theoretical and experimental validation. The development of a quasi-distributed parallel sensor array, which provides temperature compensation during measurements, has achieved a remarkable RI response sensitivity of up to 532.7 dB/RIU. The probe-type fiber optic sensitive unit, expertly functionalized with streptavidin, offers high specificity in detecting H7N9 avian influenza virus gene, with an impressively low detection limit of 10-2 pM. The development of this biosensor marks a significant development in biological detection, offering a practical engineering solution for achieving high sensitivity and specificity in light-intensity-modulated biosensing. Its potential for wide-ranging applications in various fields is now well-established.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Temperatura
/
Técnicas Biosensibles
/
Subtipo H7N9 del Virus de la Influenza A
Límite:
Animals
Idioma:
En
Revista:
Anal Chim Acta
Año:
2024
Tipo del documento:
Article
País de afiliación:
China