[How to Choose the Best Optogenetic Tool for Your Research].
Brain Nerve
; 76(7): 835-842, 2024 Jul.
Article
en Ja
| MEDLINE
| ID: mdl-38970320
ABSTRACT
All-optical methods that provide deeper understanding of neural activity are currently being developed. Optogenetics is a biological technique useful to control neuronal activity or life phenomena using light. Microbial rhodopsins are light-activated membrane proteins used as optogenetic tools. Microbial rhodopsins such as channelrhodopsin2 (ChR2) consist of seven-pass transmembrane proteins with a covalently bound retinal. Light absorption is followed by photoisomerization of the all-trans retinal to a 13-cis configuration and subsequent conformational changes in the molecule, with consequent permeability of the channel structure to ions. Recent studies have reported the discovery of microbial rhodopsins with novel functions. Microbial rhodopsin diversity has also increased. We describe the characteristics of microbial rhodopsins used as optogenetic tools and the latest research in this domain.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Optogenética
Límite:
Animals
/
Humans
Idioma:
Ja
Revista:
Brain Nerve
Asunto de la revista:
CEREBRO
/
NEUROLOGIA
Año:
2024
Tipo del documento:
Article