Your browser doesn't support javascript.
loading
Biological relapse in multiple myeloma: Outcome and treatment strategies in a Spanish real-world setting.
Alegre, Adrián; Gironella, Mercedes; Escalante, Fernando; Bergua, Juan M; Martínez-Chamorro, Carmen; López, Aurelio; González, Esther; Bárez, Abelardo; Somolinos, Nieves; Persona, Ernesto P; Cabrera, Alexia S; Soler, Alfons; Rodríguez, Belén I; López, Joaquín M; González, Yolanda; Giménez, Verónica C; Sampol, Antonia; Muñoz, Carolina; Vilanova, David; Durán, Marta; Fernández de Larrea, Carlos.
Afiliación
  • Alegre A; Hospital Universitario de la Princesa Madrid Spain.
  • Gironella M; Hospital Universitari Vall d'Hebron Barcelona Spain.
  • Escalante F; Hospital Universitario de León, León Spain.
  • Bergua JM; Hospital San Pedro de Alcántara Cáceres Spain.
  • Martínez-Chamorro C; Hospital Universitario Quirónsalud Madrid Spain.
  • López A; Hospital Universitari Arnau de Vilanova Valencia Spain.
  • González E; Hospital Universitario de Cabueñes Gijón Spain.
  • Bárez A; Hospital Nuestra Señora Sonsoles Ávila Spain.
  • Somolinos N; Hospital Universitario de Getafe Getafe Spain.
  • Persona EP; Bioaraba [Onco-Hematology Group], Vitoria-Gasteiz, Osakidetza [OSI Araba], Hospital Universitario de Álava [Department of Hematology] Vitoria-Gasteiz Spain.
  • Cabrera AS; Hospital Universitario de Gran Canaria Doctor Negrín, Las Palmas de Gran Canaria Spain.
  • Soler A; Hospital Parc Taulí Sabadell Spain.
  • Rodríguez BI; Hospital Clínico San Carlos Madrid Spain.
  • López JM; Hospital Universitario 12 de Octubre Madrid Spain.
  • González Y; Hospital Universitario Josep Trueta Girona Spain.
  • Giménez VC; Hospital de Manises Valencia Spain.
  • Sampol A; Hospital Universitario Son Espases, Palma de Mallorca Spain.
  • Muñoz C; Hospital Universitario Infanta Leonor Madrid Spain.
  • Vilanova D; Celgene S.L. Unipersonal Madrid Spain.
  • Durán M; Celgene S.L. Unipersonal Madrid Spain.
  • Fernández de Larrea C; Hospital Clínic i Provincial de Barcelona and IDIBAPS Barcelona Spain.
Hemasphere ; 8(7): e81, 2024 Jul.
Article en En | MEDLINE | ID: mdl-38974896
ABSTRACT
Recommendations regarding the best time to start treatment in patients with relapsed/refractory multiple myeloma (RRMM) after biological relapse/progression (BR) are unclear. This observational, prospective, multicenter registry aimed to evaluate the impact on time to progression (TTP) of treatment initiation at BR versus at symptomatic clinical relapse (ClinR) based on the Spanish routine practice in adult patients with RRMM. Patients had two or less previous treatment lines and at least one previous partial response. Baseline characteristics and treatment outcomes were recorded, and survival was analyzed. Of 225 patients, 110 were treated at BR (TxBR group) and 115 at ClinR (TxClinR group) according to the investigators' criteria. The proportion of patients with higher ECOG, previous noncomplete remission (CR), and second relapse were significantly higher in the TxBR group compared to the TxClinR group. TheTxClinR group showed improved outcomes, including TTP, compared to the TxBR group. Progression-free survival increased in the TxClinR group (56.2 months) compared to the TxBR group (32.5 months) (p = 0.0137), and median overall survival also increased (p = 0.0897). Median TTP was significantly longer in patients relapsing from a CR (50.4 months) and in their first relapse (38.7 months) compared to those relapsing from a non-CR response (32.9 months) and in their second relapse (25.2 months). Physicians seemed to start treatment earlier in RRMM patients with poor prognosis features. Previous responses to anti-MM treatment and the number of prior treatment lines were identified as prognosis factors, whereby relapse from CR and first relapse were associated with a longer time to progression.

Texto completo: 1 Base de datos: MEDLINE Idioma: En Revista: Hemasphere Año: 2024 Tipo del documento: Article

Texto completo: 1 Base de datos: MEDLINE Idioma: En Revista: Hemasphere Año: 2024 Tipo del documento: Article