Identification of Psychoplastogenic Tropanes Lacking Muscarinic Activity.
J Med Chem
; 67(14): 12410-12427, 2024 Jul 25.
Article
en En
| MEDLINE
| ID: mdl-38979862
ABSTRACT
Tropane-containing small molecules like scopolamine are a promising class of psychoplastogens. However, their potent antagonism of all muscarinic receptor subtypes presents the potential for undesirable anticholinergic side effects. In an effort to decouple their neuroplasticity-promoting effects from their muscarinic activity, we performed phenotypic structure-activity relationship studies across a variety of structurally distinct subclasses of tropanes. We discovered several novel tropanes capable of significantly increasing cortical neuronal growth while exhibiting drastically reduced activity at all muscarinic receptor subtypes compared to scopolamine.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Tropanos
/
Receptores Muscarínicos
Límite:
Animals
/
Humans
Idioma:
En
Revista:
J Med Chem
Asunto de la revista:
QUIMICA
Año:
2024
Tipo del documento:
Article
País de afiliación:
Estados Unidos