Characterization of Sesquiterpene Dimers from the Flowers of Inula japonica and the Structural Revisions of Related Compounds.
J Nat Prod
; 87(7): 1754-1762, 2024 Jul 26.
Article
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| MEDLINE
| ID: mdl-38982404
ABSTRACT
Sesquiterpene dimers are mainly found in the Asteraceae family. However, conflicting reports on the structures of these compounds can be found in the literature. Herein, we describe ten sesquiterpene dimers isolated from the flowers of Inula japonica, including configurational revisions of japonicone H (1-1), japonicone D (2-1), inulanolide A (4-1), japonicone X (5-1), and inulanolide F (5-2) to compounds 1, 2, 4, and 5, respectively. Five new related metabolites (3 and 6-9) are also described. Application of GIAO NMR/DP4+ analyses and ECD/OR calculations enabled us to revise the absolute configurations of an additional 13 sesquiterpene dimers isolated from plants of the genus Inula. Compounds 1, 2, 4, and 6 exhibited inhibition of nitric oxide production in lipopolysaccharide activated RAW264.7 macrophages with IC50 values of 4.07-10.00 µM.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Sesquiterpenos
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Inula
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Flores
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Óxido Nítrico
Límite:
Animals
Idioma:
En
Revista:
J Nat Prod
Año:
2024
Tipo del documento:
Article