Case report: Clinical features and management outcomes of isolated corneal intraepithelial neoplasia.
Front Ophthalmol (Lausanne)
; 4: 1346361, 2024.
Article
en En
| MEDLINE
| ID: mdl-38984137
ABSTRACT
Purpose:
To report clinical features and treatment outcome of three cases with isolated corneal intraepithelial neoplasia (CIN).Methods:
This case series presents 3 patients with isolated CIN. Data collected included, presenting signs and symptoms including vision, anterior segment examination, medical and surgical outcomes and signs and symptoms at lost post-treatment visit.Results:
Case 1 was a 45-year-old male who presented with an isolated grayish amoeboid corneal lesion which was excised with alcohol assisted epitheliectomy, he also received 6 cycles of topical mitomycin C (MMC) 0.02% and one injection of interferon alfa-2b with no recurrence during the 10-year follow-up period. Case 2 was 78-year-old male referred for a suspicious white corneal lesion which was completely excised, the patient also received 6 subconjunctival injections of interferon alpha-2b. However, the lesion recurred at 2.5-years post-treatment. Case 3 was a 63-year-old male patient who presented with an isolated corneal lesion that was excised using alcohol-assisted epitheliectomy, patient received four cycles of topical 5-fluorouracil with no recurrence at last follow-up visit at 6 months.Conclusion:
Isolated corneal intraepithelial neoplasia (CIN) is a rare entity with few reported cases in the literature. In this case series, we report long and short-term management outcomes of combined surgical and medical therapy for isolated CIN.
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Base de datos:
MEDLINE
Idioma:
En
Revista:
Front Ophthalmol (Lausanne)
Año:
2024
Tipo del documento:
Article
País de afiliación:
Arabia Saudita