The impact of iron deficiency on patients under evaluation for colorectal cancer, a prospective cross-sectional study.
Scand J Gastroenterol
; 59(9): 1055-1061, 2024 Sep.
Article
en En
| MEDLINE
| ID: mdl-38984797
ABSTRACT
BACKGROUND AND OBJECTIVE:
Iron deficiency affects more than 60% of colorectal cancer patients at the time of diagnosis. Iron deficiency ultimately leads to anemia, but additionally, iron deficiency might impact other domains of colorectal cancer patients' health and well-being. The aim of this study was to evaluate the impact of iron deficiency on fatigue, quality of life, cognition, and physical ability in patients undergoing evaluation for colorectal cancer.METHODS:
Multicenter, prospective, observational cross-sectional study (2021-2023). Fatigue was the primary outcome, measured using the Focused Assessment of Cancer Treatment-Anemia questionnaire (FACT-An). Quality of Life, Cognition, Aerobe capacity, mobility, and peripheral muscle strength were tested as secondary outcomes. Multivariate analysis was performed to estimate the impact of iron deficiency on all outcomes.RESULTS:
Two hundred and one patients were analyzed, 57% being iron deficient. In multivariate regression analysis, iron deficiency was not associated with fatigue FACT-An (r = -1.17, p = 0.57, 25% CI -5.27 to 2.92). Results on quality of life, cognition, and mobility were non-significant and with small regression coefficients. Iron deficiency showed a nearly significant association with reduced hand-grip-strength (r = -3.47 kg, p = 0.06, 25%CI -7.03 to 0.08) and reduced 6 min walking distance (r = -40.36 m, p = 0.07, 25%CI -84.73 to 4.00).CONCLUSION:
Iron deficiency in patients undergoing evaluation for colorectal cancer was not associated with fatigue, quality of life, or cognition, but might affect aerobic endurance and peripheral muscle strength to a degree that is clinically relevant.Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Calidad de Vida
/
Neoplasias Colorrectales
/
Anemia Ferropénica
/
Fatiga
Límite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Scand J Gastroenterol
Año:
2024
Tipo del documento:
Article
País de afiliación:
Dinamarca