An In Vivo High-Resolution Human Brain Atlas of Synaptic Density.
J Neurosci
; 44(33)2024 Aug 14.
Article
en En
| MEDLINE
| ID: mdl-38997157
ABSTRACT
Synapses are fundamental to the function of the central nervous system and are implicated in a number of brain disorders. Despite their pivotal role, a comprehensive imaging resource detailing the distribution of synapses in the human brain has been lacking until now. Here, we employ high-resolution PET neuroimaging in healthy humans (17F/16M) to create a 3D atlas of the synaptic marker Synaptic Vesicle glycoprotein 2A (SV2A). Calibration to absolute density values (pmol/ml) was achieved by leveraging postmortem human brain autoradiography data. The atlas unveils distinctive cortical and subcortical gradients of synapse density that reflect functional topography and hierarchical order from core sensory to higher-order integrative areas-a distribution that diverges from SV2A mRNA patterns. Furthermore, we found a positive association between IQ and SV2A density in several higher-order cortical areas. This new resource will help advance our understanding of brain physiology and the pathogenesis of brain disorders, serving as a pivotal tool for future neuroscience research.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Sinapsis
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Encéfalo
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Glicoproteínas de Membrana
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Tomografía de Emisión de Positrones
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Proteínas del Tejido Nervioso
Límite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
J Neurosci
Año:
2024
Tipo del documento:
Article
País de afiliación:
Dinamarca