Unraveling the molecular landscape of osteoarthritis: A comprehensive review focused on the role of non-coding RNAs.
Pathol Res Pract
; 260: 155446, 2024 Aug.
Article
en En
| MEDLINE
| ID: mdl-39004001
ABSTRACT
Osteoarthritis (OA) poses a significant global health challenge, with its prevalence anticipated to increase in the coming years. This review delves into the emerging molecular biomarkers in OA pathology, focusing on the roles of various molecules such as metabolites, noncoding RNAs (ncRNAs), including microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs). Advances in omics technologies have transformed biomarker identification, enabling comprehensive analyses of the complex pathways involved in OA pathogenesis. Notably, ncRNAs, especially miRNAs and lncRNAs, exhibit dysregulated expression patterns in OA, presenting promising opportunities for diagnosis and therapy. Additionally, the intricate interplay between epigenetic modifications and OA progression highlights the regulatory role of epigenetics in gene expression dynamics. Genome-wide association studies have pinpointed key genes undergoing epigenetic changes, providing insights into the inflammatory processes and chondrocyte hypertrophy typical of OA. Understanding the molecular landscape of OA, including biomarkers and epigenetic mechanisms, holds significant potential for developing innovative diagnostic tools and therapeutic strategies for OA management.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Osteoartritis
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ARN no Traducido
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Epigénesis Genética
Límite:
Animals
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Humans
Idioma:
En
Revista:
Pathol Res Pract
Año:
2024
Tipo del documento:
Article