Comparison of Complications in Patients with Ductal Cholangiocarcinoma (CCC) and Patients with Colorectal Liver Metastases (CRLMs) After Portal Vein Embolization (PVE): A Matched Cohort Study.
Cardiovasc Intervent Radiol
; 47(9): 1257-1264, 2024 Sep.
Article
en En
| MEDLINE
| ID: mdl-39009843
ABSTRACT
PURPOSE:
To compare complications in patients with cholangiocarcinoma (CCC) and patients with colorectal liver metastases (CRLMs) after portal vein embolization (PVE) and to identify possible predictive factors. MATERIAL ANDMETHODS:
Retrospective analysis of consecutive patients, who underwent PVE between July 2011 and March 2020. The study groups were matched for sex and age. Multivariable analysis was performed for the endpoints of complications categorized according for their respective effect on surgical treatment "Minor" complications had no effect on subsequent surgical treatment, while "intermediate" and "severe" complications delayed or prevented surgery.RESULTS:
A total of 160 patients with either CCC (n = 80) or CRLMs (n = 80) were included 34/160 experienced complications 27 (CCC 21; CRLMs 6) "minor", 4 (CCC 3; CRLMs 1) "intermediate", and 3 (CCC 2; CRLMs 1) "severe" complications respectively (p = .01). Patients with CCC received a biliary drainage 5 days on average before PVE. Baseline bilirubin levels were 1.1 mg/dl in CCC patients and 0.55 mg/dl in CRLMs patients (p < .01). Postinterventional infections were more common in CCC patients. The preintervention future liver remnant volume (odds ratio (OR) 0.93; 95% confidence interval (CI) 0.88-0.99; p = .02), body mass index (OR 1.19; 95% CI 1.04-1.36; p = .01), age (OR 0,91; 95% CI 0.84-0.99; p = .01), chemotherapy before PVE (OR 0.03; 95% CI 0.01-0.23; p < .01) and severe liver steatosis (OR 29.52; 95% CI 1.87-467,13; p = .02) were the only significant predictive factors for the occurrence of (minor) complications.CONCLUSION:
PVE can be performed in CCC patients with prior biliary drainage, with similar procedural safety as in patients with CRLMs.Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Vena Porta
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Neoplasias de los Conductos Biliares
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Neoplasias Colorrectales
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Colangiocarcinoma
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Embolización Terapéutica
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Neoplasias Hepáticas
Límite:
Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Cardiovasc Intervent Radiol
Año:
2024
Tipo del documento:
Article
País de afiliación:
Alemania