Timing of maternal vaccination against COVID-19 for effective protection of neonates: cohort study.
Front Immunol
; 15: 1359209, 2024.
Article
en En
| MEDLINE
| ID: mdl-39040104
ABSTRACT
Introduction:
Although the safety and effectiveness of COVID-19 vaccination during pregnancy have been proven, there is still little data explaining neonatal outcomes of maternal pre-pregnancy vaccination.Methods:
Here, we investigated the impact of vaccination and SARS-CoV-2 infection on maternal-neonate immune response in a cohort study involving 141 pregnant individuals, and defined the importance of maternal COVID-19 vaccination timing for its effectiveness. Results anddiscussion:
Our data indicate that vertically transferred maternal hybrid immunity provides significantly better antiviral protection for a neonate than either maternal post-infection or post-vaccination immunity alone. Higher neutralization potency among mothers immunized before pregnancy and their newborns highlights the promising role of pre-pregnancy vaccination in neonatal protection. A comparison of neutralizing antibody titers calculated for each dyad suggests that infection and pre-/during-pregnancy vaccination all support transplacental transfer, providing the offspring with strong passive immunity against SARS-CoV-2. Analysis of neutralizing antibody levels in maternal sera collected during pregnancy and later during delivery shows that immunization may exert a positive effect on maternal protection.Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Complicaciones Infecciosas del Embarazo
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Vacunación
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Anticuerpos Neutralizantes
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Vacunas contra la COVID-19
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SARS-CoV-2
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COVID-19
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Inmunidad Materno-Adquirida
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Anticuerpos Antivirales
Límite:
Adult
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Female
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Humans
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Newborn
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Pregnancy
Idioma:
En
Revista:
Front Immunol
Año:
2024
Tipo del documento:
Article