Population Pharmacokinetics of Dolutegravir in African Children: Results From the CHAPAS-4 Trial.
J Pediatric Infect Dis Soc
; 13(9): 496-500, 2024 Sep 26.
Article
en En
| MEDLINE
| ID: mdl-39066509
ABSTRACT
We characterized population pharmacokinetics in 42 African children receiving once-daily 25 mg (14 to <20 kg) or 50 mg (>20 kg) dolutegravir. Coadministration with emtricitabine and tenofovir alafenamide reduced dolutegravir bioavailability by 19.6% (95% confidence interval 8.13%-30.8%) compared with zidovudine or abacavir with lamivudine. Nevertheless, concentrations remained above efficacy targets, confirming current dosing recommendations.
Palabras clave
Texto completo:
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Base de datos:
MEDLINE
Asunto principal:
Oxazinas
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Piperazinas
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Piridonas
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Infecciones por VIH
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Fármacos Anti-VIH
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Compuestos Heterocíclicos con 3 Anillos
Idioma:
En
Revista:
J Pediatric Infect Dis Soc
Año:
2024
Tipo del documento:
Article
País de afiliación:
Sudáfrica