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A dual DNA-binding conjugate that selectively recognizes G-quadruplex structures.
Ooga, Mitsuharu; Sahayasheela, Vinodh J; Hirose, Yuki; Sasaki, Daisuke; Hashiya, Kaori; Bando, Toshikazu; Sugiyama, Hiroshi.
Afiliación
  • Ooga M; Department of Chemistry, Graduate School of Science, Kyoto University, Kitashirakawa-Oiwakecho, Sakyo-ku, Kyoto 606-8502, Japan. bando@kuchem.kyoto-u.ac.jp.
  • Sahayasheela VJ; Department of Chemistry, Graduate School of Science, Kyoto University, Kitashirakawa-Oiwakecho, Sakyo-ku, Kyoto 606-8502, Japan. bando@kuchem.kyoto-u.ac.jp.
  • Hirose Y; Department of Chemistry, Graduate School of Science, Kyoto University, Kitashirakawa-Oiwakecho, Sakyo-ku, Kyoto 606-8502, Japan. bando@kuchem.kyoto-u.ac.jp.
  • Sasaki D; Department of Chemistry, Graduate School of Science, Kyoto University, Kitashirakawa-Oiwakecho, Sakyo-ku, Kyoto 606-8502, Japan. bando@kuchem.kyoto-u.ac.jp.
  • Hashiya K; Department of Chemistry, Graduate School of Science, Kyoto University, Kitashirakawa-Oiwakecho, Sakyo-ku, Kyoto 606-8502, Japan. bando@kuchem.kyoto-u.ac.jp.
  • Bando T; Department of Chemistry, Graduate School of Science, Kyoto University, Kitashirakawa-Oiwakecho, Sakyo-ku, Kyoto 606-8502, Japan. bando@kuchem.kyoto-u.ac.jp.
  • Sugiyama H; Institute for Integrated Cell-Material Sciences (iCeMS), Kyoto University, Yoshida-ushinomiyacho, Sakyo-ku, Kyoto 606-8501, Japan. hs@kuchem.kyoto-u.ac.jp.
Chem Commun (Camb) ; 60(66): 8744-8747, 2024 Aug 13.
Article en En | MEDLINE | ID: mdl-39072583
ABSTRACT
G-quadruplex (G4) structures play roles in various biological processes, but the challenge lies in specific targeting. To address this, we synthesized a conjugate capable of recognizing the G4 structure and its proximal duplex. Our conjugate can enable recognition of specific G4s in the human genome to understand and target those structures.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: ADN / G-Cuádruplex Límite: Humans Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2024 Tipo del documento: Article País de afiliación: Japón
Texto completo
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PubMed Links
Buscar en Google

Texto completo: 1 Base de datos: MEDLINE Asunto principal: ADN / G-Cuádruplex Límite: Humans Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2024 Tipo del documento: Article País de afiliación: Japón