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Comparative structural study on axonemal and cytoplasmic dyneins.
Zimmermann, Noemi; Ishikawa, Takashi.
Afiliación
  • Zimmermann N; Laboratory of Nanoscale Biology, Paul Scherrer Institute, Villigen, Switzerland.
  • Ishikawa T; Department of Biology, ETH Zurich, Zürich, Switzerland.
Article en En | MEDLINE | ID: mdl-39073294
ABSTRACT
Axonemal dyneins are the driving force of motile cilia, while cytoplasmic dyneins play an essential role in minus-end oriented intracellular transport. Their molecular structure is indispensable for an understanding of the molecular mechanism of ciliary beating and cargo transport. After some initial structural analysis of cytoplasmic dyneins, which are easier to manipulate with genetic engineering, using X-ray crystallography and single-particle cryo-electron microscopy, a number of atomic and pseudo-atomic structural analyses of axonemal dyneins have been published. Currently, several structures of dyneins in the post-power stroke conformation as well as a few structures in the pre-power stroke conformation are available. It will be worth systematically comparing conformations of dynein motor proteins from different sources and at different states, to understand their role in biological function. In this review, we will overview published high- and intermediate-resolution structures of cytoplasmic and axonemal dyneins, compare the high-resolution structures of their core motor domains and overall tail conformations at various nucleotide states, and discuss their force generation mechanism.
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Texto completo: 1 Base de datos: MEDLINE Idioma: En Revista: Cytoskeleton (Hoboken) Año: 2024 Tipo del documento: Article País de afiliación: Suiza

Texto completo: 1 Base de datos: MEDLINE Idioma: En Revista: Cytoskeleton (Hoboken) Año: 2024 Tipo del documento: Article País de afiliación: Suiza