Lower diastolic tension may be indicative of higher proarrhythmic propensity in failing human cardiomyocytes.
Sci Rep
; 14(1): 17351, 2024 07 29.
Article
en En
| MEDLINE
| ID: mdl-39075069
ABSTRACT
Chronic heart failure is one of the most common reasons for hospitalization. Current risk stratification is based on ejection fraction, whereas many arrhythmic events occur in patients with relatively preserved ejection fraction. We aim to investigate the mechanistic link between proarrhythmic abnormalities, reduced contractility and diastolic dysfunction in heart failure, using electromechanical modelling and simulations of human failing cardiomyocytes. We constructed, calibrated and validated populations of human electromechanical models of failing cardiomyocytes, that were able to reproduce the prolonged action potential, reduced contractility and diastolic dysfunction as observed in human data, as well as increased propensity to proarrhythmic incidents such as early afterdepolarization and beat-to-beat alternans. Our simulation data reveal that proarrhythmic incidents tend to occur in failing myocytes with lower diastolic tension, rather than with lower contractility, due to the relative preserved SERCA and sodium calcium exchanger current. These results support the inclusion of end-diastolic volume to be potentially beneficial in the risk stratifications of heart failure patients.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Arritmias Cardíacas
/
Potenciales de Acción
/
Miocitos Cardíacos
/
Insuficiencia Cardíaca
Límite:
Humans
Idioma:
En
Revista:
Sci Rep
Año:
2024
Tipo del documento:
Article
País de afiliación:
Reino Unido