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The use of the micronucleus test and comet assay in wild rodents: a historical review and future perspectives.
Claro, Hermes Willyan Parreira; Hannibal, Wellington; Benvindo-Souza, Marcelino; de Melo E Silva, Daniela.
Afiliación
  • Claro HWP; Mutagenesis Laboratory, Instituto de Ciências Biológicas ICB I - Universidade Federal de Goiás, Avenida Esperança, S/N, Campus Samambaia, Goiânia, GO, CEP: 74.690-900, Brazil. hermeswillyanpc@gmail.com.
  • Hannibal W; Laboratory of Mammal Ecology and Biogeography, Universidade Estadual de Goiás, Campus Sudoeste, Quirinópolis, GO, CEP: 75860-000, Brazil. hermeswillyanpc@gmail.com.
  • Benvindo-Souza M; Laboratory of Mammal Ecology and Biogeography, Universidade Estadual de Goiás, Campus Sudoeste, Quirinópolis, GO, CEP: 75860-000, Brazil.
  • de Melo E Silva D; Laboratory of Aquatic Biogeography and Ecology, Universidade Estadual de Goiás, Anápolis, Goiás, Brazil.
Environ Monit Assess ; 196(8): 773, 2024 Aug 02.
Article en En | MEDLINE | ID: mdl-39090345
ABSTRACT
Rodents are considered good models for investigating genotoxic damage and mutagenic alterations caused by xenobiotic agents, due to their occupation of a wide variety of habitats. However, relatively few in situ studies have focused on DNA damage in wild rodents associated with environmental exposure. In this review, we investigate trends in the application of the micronucleus test and comet assay in in situ studies of wild rodents. A total of 33 papers were identified, distributed across 14 different countries. Brazil and Spain had the most published studies (six each), followed by Bulgaria (n = 5), Mexico (n = 4) and Italy (n = 3). Only 24 of the 2,652 recognized rodent species have been the subject of in situ studies, which have most frequently focus on species of the genus Mus. The protocols used for the micronucleus test and comet assay varied widely, although blood and bone marrow were the primary types of tissue used. Given the paucity of studies on wild rodents, we recommend further research, particularly focusing on the use of this group as bioindicators of environmental quality and the standardization of protocols.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Roedores / Daño del ADN / Pruebas de Micronúcleos / Monitoreo del Ambiente / Ensayo Cometa Límite: Animals Idioma: En Revista: Environ Monit Assess Asunto de la revista: SAUDE AMBIENTAL Año: 2024 Tipo del documento: Article País de afiliación: Brasil

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Roedores / Daño del ADN / Pruebas de Micronúcleos / Monitoreo del Ambiente / Ensayo Cometa Límite: Animals Idioma: En Revista: Environ Monit Assess Asunto de la revista: SAUDE AMBIENTAL Año: 2024 Tipo del documento: Article País de afiliación: Brasil