Histone modification in psoriasis: Molecular mechanisms and potential therapeutic targets.
Exp Dermatol
; 33(8): e15151, 2024 Aug.
Article
en En
| MEDLINE
| ID: mdl-39090854
ABSTRACT
Psoriasis is an immune-mediated, inflammatory disease. Genetic and environmental elements are involved in the nosogenesis of this illness. Epigenetic inheritance serves as the connection between genetic and environmental factors. Histone modification, an epigenetic regulatory mechanism, is implicated in the development of numerous diseases. The basic function of histone modification is to regulate cellular functions by modifying gene expression. Modulation of histone modification, such as regulation of enzymes pertinent to histone modification, can be an alternative approach for treating some diseases, including psoriasis. Herein, we reviewed the regulatory mechanisms and biological effects of histone modifications and their roles in the pathogenesis of psoriasis.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Psoriasis
/
Histonas
/
Epigénesis Genética
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Exp Dermatol
/
Exp. dermatol
/
Experimental dermatology
Asunto de la revista:
DERMATOLOGIA
Año:
2024
Tipo del documento:
Article
País de afiliación:
China