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Class A1 scavenger receptor antibody improves murine colitis by influencing macrophage and gut microbiota.
Su, Jingling; Liu, Lupeng; Ren, Yandan; Gan, Yutong; Lin, Yumei; Xie, Chenxi.
Afiliación
  • Su J; Department of Gastroenterology, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, No.201-209, Hubinnan Road, Siming District, Xiamen, 361004, Fujian Province, China.
  • Liu L; Department of Gastroenterology, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, No.201-209, Hubinnan Road, Siming District, Xiamen, 361004, Fujian Province, China.
  • Ren Y; Department of Gastroenterology, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, No.201-209, Hubinnan Road, Siming District, Xiamen, 361004, Fujian Province, China.
  • Gan Y; Department of Gastroenterology, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, No.201-209, Hubinnan Road, Siming District, Xiamen, 361004, Fujian Province, China.
  • Lin Y; Department of Gastroenterology, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, No.201-209, Hubinnan Road, Siming District, Xiamen, 361004, Fujian Province, China.
  • Xie C; Department of Gastroenterology, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, No.201-209, Hubinnan Road, Siming District, Xiamen, 361004, Fujian Province, China. fjzzxcx@163.com.
Sci Rep ; 14(1): 18618, 2024 08 10.
Article en En | MEDLINE | ID: mdl-39127850
ABSTRACT
This study aimed to investigate whether class A1 scavenger receptor (SR-A1) regulated macrophage polarization and gut microbial alteration during intestinal inflammation of colitis. A murine colitis model was established by feeding with dextran sulfate sodium (DSS), and treatment groups were injected intravenously with SR-A1 antibody. Results showed a preventive effect on colitis symptoms and fewer inflammatory cell infiltrates in treatment groups. Down-regulation of inflammatory cytokines and up-regulation of anti-inflammatory cytokine related to macrophages were seen in murine PBMC and LPMC after injected with SR-A1 antibody. The percentage of M2 macrophages was also elevated in treatment groups. In addition, SR-A1 antibody treatment resulted in the decreased apoptosis and increased proliferation of colonic epithelial cells. Other findings indicated that SR-A1 antibody injection could mediate its anti-inflammatory effect via inhibiting TLR4-MyD88-NF-kB signaling pathway and alterating the gut microbiota composition. Our research identified SR-A1 as a potential therapeutic target in inflammatory bowel disease (IBD).
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Colitis / Receptores Depuradores de Clase A / Microbioma Gastrointestinal / Macrófagos Límite: Animals Idioma: En Revista: Sci Rep Año: 2024 Tipo del documento: Article País de afiliación: China

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Colitis / Receptores Depuradores de Clase A / Microbioma Gastrointestinal / Macrófagos Límite: Animals Idioma: En Revista: Sci Rep Año: 2024 Tipo del documento: Article País de afiliación: China