Retrospective cohort study identifying pulmonary complications in a cohort of patients with systemic lupus erythematosus.
Lupus
; 33(11): 1242-1247, 2024 Oct.
Article
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| MEDLINE
| ID: mdl-39134064
ABSTRACT
BACKGROUND:
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with multi organ involvement. One of the most common manifestations is pulmonary disease with a reported prevalence between 5%-90%.PURPOSE:
Given this wide range of prevalence, there is a need to more closely define types of pulmonary disease in SLE and associated risk factors. RESEARCHDESIGN:
We sought to characterize the presentation of pulmonary manifestations in an established SLE cohort using electronic health record data. STUDY SAMPLE All patients were >18 years of age and had confirmed SLE by a rheumatologist using SLICC or 2019 ACR/EULAR classification criteria. 220 patients with imaging were included in this study; average age was 42.5 years, 86.7% identified as female, 60.5% identified as white, 37.3% as Black, and 1.82% as Asian.ANALYSIS:
Generalized estimating equations were utilized to analyze the data, accounting for its repeated measured nature.RESULTS:
We found an association between smoking (present/prior smoker) and radiologist reported disease on computerized tomography (CT) scan, as well as an association between smoking (present/prior smoker), older age, and male sex with having pulmonary disease identified on chest X-ray. The most common findings on CT and X-ray were increased lung density (24%, 12%) and atelectasis (18%, 10%). The most common disease found on CT was pleural effusion (24%) and mediastinal/axillary lymphadenopathy (16%).CONCLUSION:
While our study is limited by the retrospective nature, our results show that certain factors, namely smoking, older age, or male sex should prompt clinicians to have a higher suspicion for lung disease in SLE patients.Palabras clave
Texto completo:
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Base de datos:
MEDLINE
Asunto principal:
Tomografía Computarizada por Rayos X
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Enfermedades Pulmonares
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Lupus Eritematoso Sistémico
Límite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Lupus
Asunto de la revista:
REUMATOLOGIA
Año:
2024
Tipo del documento:
Article
País de afiliación:
Estados Unidos