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Mixed-Genotype HCV Direct Acting Antiviral Outcomes: A CANUHC Analysis.
Imsirovic, Haris; Macphail, Gisela; Conway, Brian; Fraser, Chris; Borgia, Sergio; Smyth, Daniel; Wong, Alexander; Vachon, Marie-Louise; Webster, Duncan; Liu, Hongqun; Feld, Jordan; Lee, Sam; Cooper, Curtis.
Afiliación
  • Imsirovic H; Ottawa Hospital Research Institute, Ottawa, Canada.
  • Macphail G; University of Calgary, Calgary, Canada.
  • Conway B; Vancouver Infectious Diseases Centre, Vancouver, British Columbia, Canada.
  • Fraser C; University of Victoria, Victoria, Canada.
  • Borgia S; William Osler Health System, Division of Infectious Diseases, Brampton, Canada.
  • Smyth D; McMaster University, Division of Infectious Diseases, Hamilton, Canada.
  • Wong A; Dalhousie University, Halifax, Canada.
  • Vachon ML; University of Saskatchewan, Saskatoon, Canada.
  • Webster D; Laval University, Quebec, Canada.
  • Liu H; Dalhousie University, Halifax, Canada.
  • Feld J; University of Calgary, Calgary, Canada.
  • Lee S; University of Toronto, Toronto, Canada.
  • Cooper C; University of Calgary, Calgary, Canada.
J Viral Hepat ; 31(11): 775-779, 2024 Nov.
Article en En | MEDLINE | ID: mdl-39135466
ABSTRACT
The prevalence of mixed hepatitis C virus (HCV) genotype infection in a representative Canadian HCV cohort is reported and virological response with direct acting antiviral (DAA) treatment was evaluated. 3272 HCV-positive participants were enrolled, of which 2945 (90.0%) initiated DAA therapy. 0.8% were identified with mixed genotype infection. Overall sustained virological response (SVR) was 99.1% and did not differ based on mixed genotype status. Any historical disadvantage to achieving cure with HCV treatment in mixed genotype infection has been overcome by current DAA regimens.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Antivirales / Hepacivirus / Hepatitis C Crónica / Respuesta Virológica Sostenida / Genotipo Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: America do norte Idioma: En Revista: J Viral Hepat Asunto de la revista: GASTROENTEROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Canadá
Texto completo
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PubMed Links
Buscar en Google

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Antivirales / Hepacivirus / Hepatitis C Crónica / Respuesta Virológica Sostenida / Genotipo Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: America do norte Idioma: En Revista: J Viral Hepat Asunto de la revista: GASTROENTEROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Canadá