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Paraspecific neutralization capacity of polyvalent snake antivenom against Montivipera wagneri venom.
Numanoglu Cevik, Yasemin; Serin, Metin; Altun, Derya; Namli Bozkurt, Edibe Nurzen; Turan, Ertugrul; Ercaliskan Kilic, Kubra; Bozyigit, Ilhan; Kanat, Mehmet Ali.
Afiliación
  • Numanoglu Cevik Y; Microbiology and Reference Laboratory and Biological, Products Department, General Directorate of Public Health, Turkish Ministery of Health, 06430, Ankara, Turkiye. Electronic address: cevikyasemin@yahoo.com.
  • Serin M; Microbiology and Reference Laboratory and Biological, Products Department, General Directorate of Public Health, Turkish Ministery of Health, 06430, Ankara, Turkiye. Electronic address: metin.serin@saglik.gov.tr.
  • Altun D; Microbiology and Reference Laboratory and Biological, Products Department, General Directorate of Public Health, Turkish Ministery of Health, 06430, Ankara, Turkiye. Electronic address: deryaltun2020@gmail.com.
  • Namli Bozkurt EN; Tuberculosis Department, General Directorate of Public Health, Turkish Ministery of Health, 06430, Ankara, Turkiye. Electronic address: edibe.bozkurt@saglik.gov.tr.
  • Turan E; Turkish Medicines and Medical Devices Agency, Turkish Ministery of Health, 06520, Ankara, Turkiye. Electronic address: ertugturan@hotmail.com.
  • Ercaliskan Kilic K; Albila Serum Biological Products, Eskisehir, Turkiye. Electronic address: kubraa.erc@gmail.com.
  • Bozyigit I; Turkish Medicines and Medical Devices Agency, Turkish Ministery of Health, 06520, Ankara, Turkiye. Electronic address: ilhan.bozyigit@titck.gov.tr.
  • Kanat MA; Microbiology and Reference Laboratory and Biological, Products Department, General Directorate of Public Health, Turkish Ministery of Health, 06430, Ankara, Turkiye. Electronic address: mehmetalikanat@yahoo.com.
Toxicon ; 249: 108061, 2024 Oct.
Article en En | MEDLINE | ID: mdl-39147285
ABSTRACT

PURPOSE:

This study aims to measure the paraspecific neutralization capacity of nationally produced HSGM polyvalent snake antivenom (HSGM-PSAV), produced using Macrovipera lebetina obtusa, Montivipera xanthina, and Vipera ammodytes montandoni venom, against the lethal effect of the venom of Montivipera wagneri, which is endemic to the Eastern Black Sea and Eastern Anatolia regions of Turkey.

METHODS:

The neutralization capacity of HSGM-PSAV against the lethal effect of M. wagneri venom was studied using the potency determination testing method specified in the Turkish and European Pharmacopoeia. Lethal dose 50 (LD50) values of the venoms used in immunization, M. wagneri venom in mice, and effective dose 50 (ED50) values of HSGM-PSAV against four types of venoms were calculated using two-fold dilutions.

RESULTS:

HSGM-PSAV neutralized the lethal effect of M. wagneri venom in mice. The ED50 of the HSGM-PSAV against M. wagneri venom was calculated as 304.42 LD50/mL.

CONCLUSION:

As a result of this in-vivo study, it was determined that HSGM-PSAV neutralized M.wagneri venom above the antivenom neutralization capacity threshold values (≥50 LD50/mL) specified in the Turkish and European Pharmacopoeia. This result is important preclinical data regarding the usability of HSGM-PSAV in the treatment of poisoning due to M. wagneri bites.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Antivenenos / Viperidae Límite: Animals País/Región como asunto: Asia Idioma: En Revista: Toxicon Año: 2024 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Antivenenos / Viperidae Límite: Animals País/Región como asunto: Asia Idioma: En Revista: Toxicon Año: 2024 Tipo del documento: Article