Highly efficient synthesis of enantioenriched vicinal halohydrins via Ir-catalyzed asymmetric hydrogenation using dynamic kinetic resolution.
Chem Commun (Camb)
; 2024 Aug 19.
Article
en En
| MEDLINE
| ID: mdl-39158973
ABSTRACT
A novel synthetic route was developed for the construction of chiral cis-vicinal halohydrins derivatives through Ir/f-phamidol-catalysed asymmetric hydrogenation of corresponding α-halogenated ketones with high yields (up to 99% yield), excellent diastereoselectivities (>20 1 dr), enantioselectivities (up to 99% ee), and high substrate catalyst ratio (S/C = 1000).
Texto completo:
1
Base de datos:
MEDLINE
Idioma:
En
Revista:
Chem Commun (Camb)
Asunto de la revista:
QUIMICA
Año:
2024
Tipo del documento:
Article
País de afiliación:
China