miRNA-based electrochemical biosensors for ovarian cancer.
Clin Chim Acta
; 564: 119946, 2025 Jan 01.
Article
en En
| MEDLINE
| ID: mdl-39214394
ABSTRACT
Ovarian cancer, a prevalent and deadly cancer among women, presents a significant challenge for early detection due to its heterogeneous nature. MicroRNAs, short non-coding regulatory RNA fragments, play a role in various cellular processes. Aberrant expression of these microRNAs has been observed in the carcinogenesis-related processes of many cancer types. Numerous studies highlight the critical role of microRNAs in the initiation and progression of ovarian cancer. Given their clinical importance and predictive value, there has been considerable interest in developing simple, prompt, and sensitive miRNA biosensor strategies. Among these, electrochemical sensors have demonstrated advantageous characteristics such as simplicity, sensitivity, low cost, and scalability. These microRNA-based electrochemical biosensors are valuable tools for early detection and point-of-care applications. This article discusses the potential role of microRNAs in ovarian cancer and recent advances in the development of electrochemical biosensors for miRNA detection in ovarian cancer samples.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Neoplasias Ováricas
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Técnicas Biosensibles
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MicroARNs
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Técnicas Electroquímicas
Límite:
Female
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Humans
Idioma:
En
Revista:
Clin Chim Acta
Año:
2025
Tipo del documento:
Article
País de afiliación:
Irán