Salivary Short-chain Fatty Acids (SCFAs) Are Viable Predictors of Early Changes in Systemic Health.
Chin J Dent Res
; 27(3): 193-202, 2024 Sep 02.
Article
en En
| MEDLINE
| ID: mdl-39221980
ABSTRACT
Short-chain fatty acids (SCFAs) are the metabolites identified in both the oral cavity and the gut. They play an important role in the triggering, development and progression of systemic diseases. SCFAs can alter the gut microbial components, intestinal epithelium and host immune system, and are also associated with cancer incidence. Salivary SCFAs, produced by the oral microbiome, are correlated with some oral diseases. The occurrence of systemic diseases associated with gut SCFAs is more clearly defined than oral SCFAs. Salivary SCFAs can enter the bloodstream directly via inflamed gingiva to cause continuous low-grade systemic inflammation. Hence, salivary SCFAs could be an indicator for the early diagnosis of systemic diseases. Furthermore, they provide a basis for understanding the oral-systemic axis driven through salivary SCFAs in the pathogenesis of several diseases.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Saliva
/
Ácidos Grasos Volátiles
Límite:
Humans
Idioma:
En
Revista:
Chin J Dent Res
Asunto de la revista:
ODONTOLOGIA
Año:
2024
Tipo del documento:
Article