Clinical-transcriptional prioritization of the circulating proteome in human heart failure.
Cell Rep Med
; 5(9): 101704, 2024 Sep 17.
Article
en En
| MEDLINE
| ID: mdl-39226894
ABSTRACT
Given expanding studies in epidemiology and disease-oriented human studies offering hundreds of associations between the human "ome" and disease, prioritizing molecules relevant to disease mechanisms among this growing breadth is important. Here, we link the circulating proteome to human heart failure (HF) propensity (via echocardiographic phenotyping and clinical outcomes) across the lifespan, demonstrating key pathways of fibrosis, inflammation, metabolism, and hypertrophy. We observe a broad array of genes encoding proteins linked to HF phenotypes and outcomes in clinical populations dynamically expressed at a transcriptional level in human myocardium during HF and cardiac recovery (several in a cell-specific fashion). Many identified targets do not have wide precedent in large-scale genomic discovery or human studies, highlighting the complementary roles for proteomic and tissue transcriptomic discovery to focus epidemiological targets to those relevant in human myocardium for further interrogation.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Proteoma
/
Insuficiencia Cardíaca
/
Miocardio
Límite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Cell Rep Med
/
Cell reports medicine
Año:
2024
Tipo del documento:
Article
País de afiliación:
Estados Unidos