Your browser doesn't support javascript.
loading
COMPARING vaccine manufacturing technologies recombinant DNA vs in vitro transcribed (IVT) mRNA.
Davidopoulou, Christina; Kouvelas, Dimitrios; Ouranidis, Andreas.
Afiliación
  • Davidopoulou C; Department of Chemical Engineering, Aristotle University of Thessaloniki, 54124, Thessaloniki, Greece.
  • Kouvelas D; Department of Clinical Pharmacology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece.
  • Ouranidis A; Department of Chemical Engineering, Aristotle University of Thessaloniki, 54124, Thessaloniki, Greece. ouranidis@auth.gr.
Sci Rep ; 14(1): 21742, 2024 09 18.
Article en En | MEDLINE | ID: mdl-39289418
ABSTRACT
Vaccine manufacturing fosters the prevention, control, and eradication of infectious diseases. Recombinant DNA and in vitro (IVT) mRNA vaccine manufacturing technologies were enforced to combat the recent pandemic. Despite the impact of these technologies, there exists no scientific announcement that compares them. Digital Shadows are employed in this study to simulate each technology, investigating root cause deviations, technical merits, and liabilities, evaluating cost scenarios. Under this lens we provide an unbiased, advanced comparative technoeconomic study, one that determines which of these manufacturing platforms are suited for the two types of vaccines considered (monoclonal antibodies or antigens). We find recombinant DNA technology to exhibit higher Profitability Index due to lower capital and starting material requirements, pertaining to lower Minimum Selling Price per Dose values, delivering products of established quality. However, the potency of the mRNA, the streamlined and scalable synthetic processes involved and the raw material availability, facilitate faster market penetration and product flexibility, constituting these vaccines preferable whenever short product development cycles become a necessity.
Asunto(s)
Palabras clave

Texto completo: 1 Base de datos: MEDLINE Asunto principal: ARN Mensajero Límite: Humans Idioma: En Revista: Sci Rep Año: 2024 Tipo del documento: Article País de afiliación: Grecia

Texto completo: 1 Base de datos: MEDLINE Asunto principal: ARN Mensajero Límite: Humans Idioma: En Revista: Sci Rep Año: 2024 Tipo del documento: Article País de afiliación: Grecia