Are histomorphological patterns a predictor for survival in uveal melanoma patients with hepatic metastases undergoing hepatic artery infusion chemotherapy?
J Med Imaging Radiat Oncol
; 2024 Sep 24.
Article
en En
| MEDLINE
| ID: mdl-39315695
ABSTRACT
INTRODUCTION:
In uveal melanoma (UM) patients with hepatic metastases, hepatic artery infusion chemotherapy (HAIC) is a viable, palliative treatment option. To evaluate the impact of two histomorphological patterns (spindle cell vs. epithelioid) of liver metastases on median overall survival (mOS) in UM patients undergoing HAIC.METHODS:
A retrospective analysis with 60 UM patients (29 females, mean age 61.6 ± 12.1 years) with hepatic metastases was performed. Histomorphological patterns in metastases were analysed and classified as either predominant spindle cell or epithelioid pattern. mOS between both patient groups was analysed using Kaplan-Meier curves and the log-rank test.RESULTS:
In 73.3% (44/60) of the metastases, a predominant epithelioid pattern, in 21.7% (13/60) a predominant spindle cell pattern, and in 5% (3/60) other patterns were found. No significant differences between patients with an epithelioid (mOS 14.2 months, 95% CI 8.8-19.6) and a spindle cell pattern (mOS 14.4 months, 95% CI 4.3-24.5) were detected by the log-rank test, χ2(2) = 0.22, P = 0.881.CONCLUSION:
Histomorphological patterns of UM metastases do not seem to be a predictor for mOS in UM patients undergoing HAIC.
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Base de datos:
MEDLINE
Idioma:
En
Revista:
J Med Imaging Radiat Oncol
Asunto de la revista:
DIAGNOSTICO POR IMAGEM
/
NEOPLASIAS
/
RADIOLOGIA
Año:
2024
Tipo del documento:
Article
País de afiliación:
Alemania