Posttransfusion non-A, non-B hepatitis: physicochemical properties of two distinct agents.
J Infect Dis
; 148(2): 254-65, 1983 Aug.
Article
en En
| MEDLINE
| ID: mdl-6411832
ABSTRACT
Two separate and distinct episodes of non-A, non-B hepatitis were induced in each of two chimpanzees by two inocula one containing a chloroform-resistant agent and the other containing a chloroform-sensitive agent. Both agents were recovered from liver tissue and plasma obtained from a single chimpanzee during the acute and chronic phases of infection with a factor VIII concentrate, respectively. The chloroform-resistant agent did not cause unique changes in hepatocytes; in contrast, the chloroform-sensitive agent did induce the formation of cytoplasmic tubules, convoluted endoplasmic reticulum, and dense reticular inclusion bodies. The latter changes are similar in character to those induced in infected cells by some enveloped mammalian RNA viruses.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Transfusión Sanguínea
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Hepatitis C
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Hepatitis Viral Humana
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Virus de Hepatitis
Límite:
Animals
Idioma:
En
Revista:
J Infect Dis
Año:
1983
Tipo del documento:
Article