Inactivation of hepatitis B virus by intermediate-to-high-level disinfectant chemicals.
J Clin Microbiol
; 18(3): 535-8, 1983 Sep.
Article
en En
| MEDLINE
| ID: mdl-6630443
ABSTRACT
In five separate tests, hepatitis B virus in dried human plasma was exposed for 10 min at 20 degrees C to disinfectant chemicals having activity levels ranging from intermediate (e.g., 70% isopropyl alcohol) to high (e.g., 2% aqueous glutaraldehyde at pH 8.6). Five chimpanzees (one animal per disinfectant chemical) received treated material intravenously, and none showed signs of infection after post-inoculation periods of 9 months. Two animals were rechallenged with inoculum treated in the same manner, except that saline was used instead of a disinfectant chemical; both were infected within 4 weeks. Our results showed that hepatitis B virus was not as resistant to disinfectant chemicals as once thought and suggested that chemicals with similar activity levels (intermediate to high) might possibly be used on hepatitis B virus contamination with a margin of safety.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Virus de la Hepatitis B
/
Desinfectantes
Límite:
Animals
Idioma:
En
Revista:
J Clin Microbiol
Año:
1983
Tipo del documento:
Article