[Central nervous system relapses in acute lymphoblastic leukemia and different methods of prophylaxis]. / Wznowy w osrodkowym ukladzie nerwowym w przebiegu ostrej bialaczki limfoblastycznej a sposób postepowania profilaktycznego.
Acta Haematol Pol
; 26(1): 47-56, 1995.
Article
en Pl
| MEDLINE
| ID: mdl-7747562
ABSTRACT
The results of two different methods of CNS prophylaxis during consolidation were evaluated among fifty one acute lymphoblastic leukemia patients (ALL) treated in 1980-1991 in the Department of Hematology in Katowice. In group I (n = 28) methotrexate (Mtx) was used intrathecally (it) in 6 doses of 18 mg, in group II high dose cytosine arabinoside (Hi AraC)--3g/m2 intravenously (4x) was used with CNS rtg--therapy (18-24Gy). In both groups frequency of CNS relapses was similar 17.8% vs 17.3%; additionally there were no statistically significant differences in RFS 369 vs. 562 days. The survival of patients with and without CNS relapses was also similar (678 vs. 774 days) and was independent of prophylaxis. The tolerance of both the used methods of CNS prophylaxis was good.
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Base de datos:
MEDLINE
Asunto principal:
Neoplasias del Sistema Nervioso Central
/
Leucemia-Linfoma Linfoblástico de Células Precursoras
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Límite:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
Pl
Revista:
Acta Haematol Pol
Año:
1995
Tipo del documento:
Article