Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma.
Science
; 266(5192): 1865-9, 1994 Dec 16.
Article
en En
| MEDLINE
| ID: mdl-7997879
ABSTRACT
Representational difference analysis was used to isolate unique sequences present in more than 90 percent of Kaposi's sarcoma (KS) tissues obtained from patients with acquired immunodeficiency syndrome (AIDS). These sequences were not present in tissue DNA from non-AIDS patients, but were present in 15 percent of non-KS tissue DNA samples from AIDS patients. The sequences are homologous to, but distinct from, capsid and tegument protein genes of the Gammaherpesvirinae, herpesvirus saimiri and Epstein-Barr virus. These KS-associated herpesvirus-like (KSHV) sequences appear to define a new human herpesvirus.
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Base de datos:
MEDLINE
Asunto principal:
Sarcoma de Kaposi
/
ADN Viral
/
Síndrome de Inmunodeficiencia Adquirida
/
Herpesviridae
Tipo de estudio:
Diagnostic_studies
/
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Límite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
Science
Año:
1994
Tipo del documento:
Article