Properdin, a positive regulator of complement activation, is expressed in human T cell lines and peripheral blood T cells.
J Immunol
; 151(5): 2521-8, 1993 Sep 01.
Article
en En
| MEDLINE
| ID: mdl-8360474
ABSTRACT
Properdin plays an important regulatory role in the activation of the complement system. Here we report the biosynthesis of properdin in four different human T cell lines and in T cells purified from peripheral blood. Cell sorting experiments, in conjunction with Northern blotting, showed that both CD4- and CD8-bearing populations of T cells have the potential to synthesize properdin. The functional activity of properdin secreted from these T cell lines was determined in a hemolytic assay. In view of the numerous ways in which complement activation may influence cellular immune response, the present results indicate, for the first time, a possible interaction between the complement and the T cell system.
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Base de datos:
MEDLINE
Asunto principal:
Properdina
/
Linfocitos T
/
Activación de Complemento
Límite:
Adult
/
Humans
Idioma:
En
Revista:
J Immunol
Año:
1993
Tipo del documento:
Article
País de afiliación:
Alemania