Neurotrophin receptor proteins immunoreactivity in the rat cerebellar cortex as a function of age.
Mech Ageing Dev
; 83(1): 1-9, 1995 Aug 31.
Article
en En
| MEDLINE
| ID: mdl-8523897
ABSTRACT
The influence of age on immunohistochemically demonstrable neurotrophin receptor proteins (p75, trkA-, trkB-, and trkC-proteins) was studied in the cerebellar cortex of Wistar male rats aged 3 (young), 12 (adult) and 24 (old) months. The number of Purkinje neurons displaying p75, trkA- and trkC-like proteins immunoreactivity (IR), as well as the intensity of p75 and trkA-like protein IR, were significantly reduced in aged rats in comparison with 3 and 12-month-old rats. The intensity of trkC-like protein in the cytoplasm of Purkinje neurons remained unchanged for all the period studied. Moreover, no significant age-dependent changes were observed in the density of p75 or trkC-like proteins IR in the granule neurons layer. The molecular layer showed faint p75 IR which decreased as a function of age. No immunolabelling for neuronal trkB-like proteins was observed, but trkB- and trkC-like proteins IR was found in non-neuronal cells. These results suggest that cerebellar cortex neurons are responsive to and/or dependent upon different neurotrophins. Moreover, the age-dependent impairment in the expression of some neurotrophin receptors in Purkinje neurons, but not in the granule neurons, lends support to a role for neurotrophins in cerebellar aging.
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Base de datos:
MEDLINE
Asunto principal:
Proteínas Tirosina Quinasas
/
Envejecimiento
/
Proteínas
/
Corteza Cerebral
Límite:
Animals
Idioma:
En
Revista:
Mech Ageing Dev
Año:
1995
Tipo del documento:
Article
País de afiliación:
España