The gene for human glutaredoxin (GLRX) is localized to human chromosome 5q14.
Genomics
; 32(3): 455-7, 1996 Mar 15.
Article
en En
| MEDLINE
| ID: mdl-8838810
ABSTRACT
Glutaredoxin is a small protein (12 kDa) catalyzing glutathione-dependent disulfide oxidoreduction reactions in a coupled system with NADPH, GSH, and glutathione reductase. A cDNA encoding the human glutaredoxin gene (HGMW-approved symbol GLRX) has recently been isolated and cloned from a human fetal spleen cDNA library. The screening of a human genomic library in Charon 4A led to the identification of three genomic clones. Using fluorescence in situ hybridization to metaphase chromosomes with one genomic clone as a probe, the human glutaredoxin gene was localized to chromosomal region 5q14. This localization at chromosome 5 was in agreement with the somatic cell hybrid analysis, using DNA from a human-hamster and a human-mouse hybrid panel and using a human glutaredoxin cDNA as a probe.
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Base de datos:
MEDLINE
Asunto principal:
Oxidorreductasas
/
Cromosomas Humanos Par 5
/
Proteínas
/
Mapeo Cromosómico
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Genomics
Asunto de la revista:
GENETICA
Año:
1996
Tipo del documento:
Article