Regulation of neuronal survival by the serine-threonine protein kinase Akt.
Science
; 275(5300): 661-5, 1997 Jan 31.
Article
en En
| MEDLINE
| ID: mdl-9005851
ABSTRACT
A signaling pathway was delineated by which insulin-like growth factor 1 (IGF-1) promotes the survival of cerebellar neurons. IGF-1 activation of phosphoinositide 3-kinase (PI3-K) triggered the activation of two protein kinases, the serine-threonine kinase Akt and the p70 ribosomal protein S6 kinase (p70(S6K)). Experiments with pharmacological inhibitors, as well as expression of wild-type and dominant-inhibitory forms of Akt, demonstrated that Akt but not p70(S6K) mediates PI3-K-dependent survival. These findings suggest that in the developing nervous system, Akt is a critical mediator of growth factor-induced neuronal survival.
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Base de datos:
MEDLINE
Asunto principal:
Factor I del Crecimiento Similar a la Insulina
/
Transducción de Señal
/
Proteínas Proto-Oncogénicas
/
Proteínas Serina-Treonina Quinasas
/
Apoptosis
/
Neuronas
Límite:
Animals
Idioma:
En
Revista:
Science
Año:
1997
Tipo del documento:
Article
País de afiliación:
Estados Unidos