Therapeutic potential of antiidiotypic single chain antibodies with yeast killer toxin activity.
Nat Biotechnol
; 15(2): 155-8, 1997 Feb.
Article
en En
| MEDLINE
| ID: mdl-9035141
ABSTRACT
Single chain fragment (ScFv) antiidiotypic antibodies (antilds) of a killer toxin (KT) from the yeast Pichia anomala have been produced by recombinant DNA methodology from the splenic lymphocytes of mice immunized by idiotypic vaccination with a KT-neutralizing monoclonal antibody (Mab KT4). ScFv KT-like antilds (KTIdAb) react with specific Candida albicans KT cell wall receptors (KTR) exerting a candidacidal activity in vitro could be neutralized by adsorption with Mab KT4. ScFv KTIdAb displayed an effective therapeutic activity in an experimental model of rat candidal vaginitis.
Buscar en Google
Base de datos:
MEDLINE
Asunto principal:
Candidiasis Vulvovaginal
/
Anticuerpos Antiidiotipos
/
Inmunotoxinas
/
Anticuerpos Monoclonales
/
Micotoxinas
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Nat Biotechnol
Asunto de la revista:
BIOTECNOLOGIA
Año:
1997
Tipo del documento:
Article
País de afiliación:
Italia