Synthesis and biological activity of acylated and telomerized peptides as potential HIV-fixation inhibitors.
Farmaco
; 51(12): 767-73, 1996 Dec.
Article
en En
| MEDLINE
| ID: mdl-9050208
ABSTRACT
In order to inhibit the gp 120-CD4 glycoprotein interaction, a key step of the HIV-infection, we have synthesized a series of N-acylated peptides containing sequences identified in both the viral and lymphocytic proteins, (SDFR, SDAR, RFDSAARFDS, DRADSRRS, PSKLNDRADSRRSLWD, ASTTTNYT). An hydrophobic moiety (capryloyl, palmitoyl acrylamidoundecanoyl) was introduced in the last step of interactive synthesis, in homogeneous or solid phase. The acrylogyl-containing compounds were then telomerized under UV irradiation (DPn observed 2 to 6). The biological evaluation shown an antiviral effect in vitro for telomerized peptides containing amino diacids such as Glu and Asp.
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Base de datos:
MEDLINE
Asunto principal:
Péptidos
/
Fármacos Anti-VIH
Límite:
Humans
Idioma:
En
Revista:
Farmaco
Asunto de la revista:
FARMACOLOGIA
/
QUIMICA
Año:
1996
Tipo del documento:
Article
País de afiliación:
Francia