Lack of the specific influence of histamine and histamine H1, H2 and H3 receptor ligands on the serotonin uptake and release in rat blood platelets.
Pol J Pharmacol
; 48(6): 615-20, 1996.
Article
en En
| MEDLINE
| ID: mdl-9112702
This work was designed to investigate the influence of histamine, and H1 receptor agonist 2-(2-thiazolyl)ethylamine, H2 receptor agonist dimaprit and H3 receptor agonist R-(-)-alpha-methylhistamine on the serotonin uptake and release in rat blood platelets. Histamine and R-(-)-alpha-methylhistamine (up to 1 mmol/l), 2-(2-thiazolyl)ethylamine (up to 10 mumol/l) and dimaprit (up to 1 mumol/l) failed to affect the serotonin uptake. The concentration-dependent inhibitory effects of higher concentrations of 2-(2-thiazolyl)ethylamine and dimaprit (up to 1 mmol/l) were not diminished by the H1 receptor antagonist dimetindene and the H2 receptor antagonist ranitidine (1 and 100 mumol/l each), respectively. Histamine, 2-(2-thiazolyl)ethylamine, dimaprit and R-(-)-alpha-methylhistamine (up to 10 mumol/l) did not change the serotonin release from rat blood platelets. Our results demonstrate that histamine and histamine H1, H2 and H3 receptor agonists do not affect in a specific manner the serotonin uptake and release in rat blood platelets.
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Base de datos:
MEDLINE
Asunto principal:
Tiazoles
/
Plaquetas
/
Metilhistaminas
/
Serotonina
/
Agonistas de los Receptores Histamínicos
/
Dimaprit
Límite:
Animals
Idioma:
En
Revista:
Pol J Pharmacol
Asunto de la revista:
FARMACOLOGIA
Año:
1996
Tipo del documento:
Article
País de afiliación:
Polonia