Unbalanced X;autosome translocation (X;18)(q13;p11) in a case of aggressive natural killer non-Hodgkin lymphoma.
Cancer Genet Cytogenet
; 98(1): 16-9, 1997 Oct 01.
Article
en En
| MEDLINE
| ID: mdl-9309113
ABSTRACT
Recent evidence has shown that rare cases of aggressive non-Hodgkin lymphomas (NHL) derive from cells belonging to the natural killer (NK) lymphocyte lineage and a new clinico pathologic entity has been proposed. Though well documented in B- and T-cell NHL, chromosome abnormalities are rare findings in NK-NHL and to date, no recurrent cytogenetic abnormality has been described. The present study reports the clinical data, cytogenetic and fluorescence in situ hybridization (FISH) analysis of a new case of typical NK-NHL characterized by a primary unbalanced translocation (X;18) (q13;p11). Recent data of X;autosome translocation in malignant lymphomas have proposed Xp22 and Xq28 as the location of NHL-related oncogenes. According to other published reports on the involvement of the Xq13 region in NHL and particularly in aggressive forms, we hypothesize the existence of additional putative lymphoma-associated oncogenes at the band Xq13.
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Base de datos:
MEDLINE
Asunto principal:
Translocación Genética
/
Cromosoma X
/
Cromosomas Humanos Par 18
/
Linfoma no Hodgkin
/
Células Asesinas Naturales
Límite:
Adult
/
Female
/
Humans
Idioma:
En
Revista:
Cancer Genet Cytogenet
Año:
1997
Tipo del documento:
Article
País de afiliación:
Francia